1. My habits were great before I started - diet, exercise, no food attachment or emotional eating issues. My insulin on the other hand was resistant. No diabetes, dawn phenomenon in the mornings. Now I’m losing with semaglutide. If I stop I may still be insulin resistant and gain again.

  2. I believe that LionelHutz2018 and theclafinn got it exactly right. Weight regain after stopping semaglutide was shown to be the norm in the real world trial "The STEP 1 trial extension"

  3. Some people are losing weight with unsustainable ways. I’ve seen people bragging about eating peppermints all day. That’s cool you can drop some weight but if you’re not addressing what got you to be overweight the cycle will continue.

  4. I have a different question. Why is it assumed we will stop talking any GLP 1? Nobody questions, for example, that I have been on cholesterol and blood pressure medicine for a decade. I genuinely don't understand why this stuff has treated differently, particularly if it can help get me off those drugs.

  5. I have a friend who was on jt for almost a year.. lost an INSANE amount of weight ( she legit looked sick). Her doctor wanted to to stop because she was at a super unhealthy weight. She did gain back almost all of it because even the she did learn to make better food choices abs habits, once you are off of it, you now have an appetite again. The beauty of this drug is you just don’t have an appetite so for me, over eating is no longer an issue….

  6. What was your bmi when you started and do you hav insulin resistance? I wonder about some Of this because I have some IR, but my bmi was just 27, so not obese, hoping that the loss will have helped my IR and then it’ll be easier to keep off, plus I’ll be tapering down.

  7. There is a hard truth in that statement. Statistically speaking, it's harder to lose weight and keep it off than it is to successfully quit smoking permanently.

  8. It’s not a matter of “willpower.” It’s the body trying to maintain the body weight you’ve been at for many years. This is the main obstacle for weight loss, this homeostatic maintenance of set point. Decades of obesity research support this and the main innovation behind semaglutide’s success is that it suppresses the ramping of hunger to maintain a constant weight (the setpoint system), not simply that it suppresses appetite in general.

  9. Psychologically, you won't be able to maintain it, just like you were not able to before taking the semaglutide. You'll get hungrier and faster. The drug also works on your brain in a way that makes you crave less. Eventually the cravings and old eating patterns will return, most likely.

  10. If your body returns to normal functioning because of weight loss, then willpower may be enough to maintain the newest weight (plus some water weight from moving back up to maintainance calories). Weight loss does reduce insulin resistance, but it does little to change the pre-medication leptin resistance.

  11. The leptin resistance is key. If you’re done losing weight and immediately go off the medication, your leptin levels are going to be very low. They could go up higher over time, though studies need to be done on this.

  12. This is the key for me. Since the leading cause of Leptin resistance is high levels of Leptin, I'm hoping that it will turn out that sustaining a lower weight for a few years will increase Leptin sensitivity. I feel like I could sustain the lower weight without medication if only my body recognized the Leptin signals and gave me normal hunger cues.

  13. This statement is true. Prior to this I was on Saxenda and when I stopped I gained everything back plus some. This drug is entended to be a long term drug. Doctor even mentiond life time drug.

  14. It’s bc your body will more likely than not reduce your BMR forcing you to then lower your calorie intake again. It will keep doing this until it (you body) achieves its desired setpoint.

  15. This is very discouraging. I have been trying to lose weight all my life, tried so many diets, and exercise, and therapy, and I feel I can’t do this anymore. I need some medical help. If I manage to go back to a normal weight range while I continue to exercise, I hope that I will be able to maintain it. Or even if I get some back, it will not be all.

  16. I think the key will be obesity being treated more as the chronic illness it is. The difference here is we can see the weight or the lack of weight (once it is lost) unlike HBP or diabetes (the things we can’t see).

  17. These are findings from the research but I hope this will not incorrectly dissuade anyone from taking the drug. Do your own risk analysis. In my case if this drug had not come along, there's a high likelihood I'd be dead in 5 years, the same age my fat grandfather had his last and fatal heart attack. So I'm calculating if I take this and stay thin for 10 years and then stop and get fat again and die right away of obesity, I'm still living 5 years longer than I would have otherwise. Hopefully by that time they'll have developed better protocols for dealing with long-term use.

  18. Yeah it’s pretty dumb. Yes, if you go back to old habits, you will gain it back. I have yo yo dieted for years. I have lost tons of weight, maintained it for years, the. Eventually gained it all back. It just takes consistency and discipline

  19. I'm hoping to stop. I didn't have anything like insulin resistance and was maintaining a previous 45 lbs weight loss. I just couldn't drop my calories low enough while being so active (1.5-2.5 hours a day I'm a fitness instructor) and not starving to lose the next 40. I'm fine with counting calories forever.

  20. High percentage of people eat foods that promote obesity & obsessive hunger. Dieting, calorie cutting, eating less, taking drugs to lose weight often results in weight regain after going off the diet or the drug. Their food choices & eating frequency, often low metabolic rate in a high percentage of cases, puts them back into weight regain. Others who change their nutrition, their lifestyles & build an increased metabolic rate & better health will be more successful in weight maintenance. Nutrition & feeding frequency changes, healthier lifestyles is a more successful strategy that can be continued for life, rather than ending when a weight goal is reached. There are other factors such as biological metabolic, disease processes that cannot be fully resolved even with ideal nutrition & lifestyle changes.

  21. If you were doing what you did before and you start doing it again yeah that's what's going to happen but if you try to learn and maintain and be in touch with yourself it's amazing with a little brain power can do.

  22. Because the studies show that's true. Some gain a bit, some gained all back, Some gained more than they lost. More than 80% regained once stopping the drug.

  23. It depends. Hopefully everyone is working closely with their physician and using the time while on Semaglutide to make healthy lifestyle changes.

  24. I think they say it because of how your hunger comes back so intensely as well as it being difficult when you’re hungry to make as good of food choices as when you didn’t have the same level of hunger on the med.

  25. I lost 20 lbs (had 20 to go), have PCOS and IR, and since I can’t get my prescription filled anywhere I’ve now gained 7 lbs despite trying my best to continue exercising/eating well. Hunger is real.

  26. It depends on whether you keep to healthy eating when you stop the medicine. I know, this is obvious, but it's the answer. To keep the weight off, you have to find a healthy food regimen and keep with it for the rest of your life. I'm doing that now because I'm committed to not gaining the weight back. I'll never be able to gorge on sweets again. I have to reconcile myself to that.

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